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Calciseptine
Calciseptine
Potent, specific L-type Ca2+ channel blocker (IC50 = 15 nM). Inactive on other voltage-dependent Ca2+ channels. Smooth muscle relaxant and cardiacontraction inhibitor. Neurotoxic. Active in vivo and in vitro.
Calcicludine
Calcicludine
L-type Ca2+ channels. Calcicludine is a potent and specific antagonist of neuronal L-type CaV channels1.
ω conotoxin GVIA
ω conotoxin GVIA
Ca2+ channel blocker (N type), Synthetic toxin originally isolated from Conus geographus. Specific blocker of Cav2.2 (N-type) Ca2+ channels. Binds to the Cav2.2α1 subunit (α1B) and its action is only partially reversible.
ω agatoxin IVA
ω agatoxin IVA
P-type Ca2+ channels. ω-Agatoxin IVA is an antagonist of voltage-sensitive P-type Ca2+ channels1. It blocks neuromuscular transmission presynaptically in a variety of synapses2,3.
ω agatoxin IVB
ω agatoxin IVB
P-type and Q-type Ca2+ channels, ω-Agatoxin TK is an antagonist of voltage-sensitive P-type Ca2+ channels1
SNX482
SNX482
R-Type Ca2+ (Cav2.3) channel blocker. Peptide toxin that naturally occurs in the venom of the spider Hysterocrates gigas. Selectively blocks Cav2.3 (α1E, R-type) channels in a voltage dependent manner (IC50 = 15-30 nM). At higher concentrations, also blocks Cav2.1 channels in chromaffin cells.
kurtoxin
kurtoxin
Kurtoxin is a compound found in scorpion toxin, and is a T-type Ca2+ channel blocker
PLTX II
PLTX II
Selective, irreversible presynaptic voltage-gated Ca2+ channel blocker. Potent neurotoxin. Selective exocytosis inhibitor. Shows insecticidal effects in vivo.
μ conotoxin GIIIA
μ conotoxin GIIIA
A Blocker of NaV1.4 Na+ Channel, µ-Conotoxin GIIIA is a NaV1.4 channel blocker1,2.
huwentoxin IV
huwentoxin IV
TTX-sensitive Na+ channels, Huwentoxin-IV specifically inhibits the neuronal tetrodotoxin-sensitive (TTX-S) voltage-gated Na+ channel (IC50 = 30 nM) in adult rat dorsal root ganglion neurons, while having no significant effect on the tetrodotoxin-resistant (TTX-R) voltage-gated Na+ channel1-3.
Protoxin II
Protoxin II
NaV channels and T-type Ca2+ channels, ProTx-II inhibits NaV channels1. ProTx-II could also modulate T-type Ca2+ channels at higher concentrations2.
ShK Toxin
ShK Toxin
Various KV K+ channels. Stichodactyla Toxin blocks KV1.3, KV1.1, KV1.4, and KV1.6 at subnanomolar concentrations and KV3.2 channels at 1000-fold higher concentration than that required to inhibit KV1.3 channels.
Margatoxin
Margatoxin
Kv1.3 selective blocker.
Dendrotoxin I
Dendrotoxin I
KV1.1, KV1.2 K+ channels, Dendrotoxin-I is a highly selective blocker of voltage-gated K+ channels (KV1.1 and KV1.2), as well as heteromultimeric channels containing these, with other KV1 isoforms1. The inhibition effect is higher in Xenopus oocytes compared to mammalian cells2.
Iberiotoxin
Iberiotoxin
KCa1.1 K+ channels, Iberiotoxin is a potent selective blocker of the high conductance Ca2+-activated K+ channels (maxi-K).
Kaliotoxin
Kaliotoxin
Potent blocker of voltage-sensitive K+ channels (IC50 values are 0.1, 1.1 and 25 nM for KV1.3, KV1.1 and KV1.2 channels) respectively). Also inhibits Ca2+-activated K+ channels.
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