• Promote Academic Exchanges, Focus on Human Health<br> ——KS-V Peptide Attended ASBMB-BSC International Conference on Genome Stability and Performance Genetic Regulation
    Promote Academic Exchanges, Focus on Human Health
    ——KS-V Peptide Attended ASBMB-BSC International Conference on Genome Stability and Performance Genetic Regulation
    Oct 29, 2019
    The four-day International Conference on Genome Stability and Performance Genetic Regulation was successfully concluded in Suzhou on October 24. The theme of this conference is "Epigenetics and Human Health". The International Conference on Genome Stability and Performance Genetic Regulation is jointly organized by Biophysical Society of China (BSC) and American Society for Biochemistry and Molecular Biology (ASBMB).The conference is planned to be held every two years in turn in China and the United States, sponsored by BSC and ASBMB respectively. KS-V Peptide participated in the conference as a platinum sponsor. While focusing on high-quality peptide products and services, KS-V Peptide are committed to promoting the research and development of innovative peptide drugs. And KS-V Peptide also pay attention to the trends of relevant academic conferences and supporting the development of scientific researches actively. During the conference, KS-V Peptide provided some free samples for universities and scientific research institutes for trial use. Dr. Guo Xiaoqi, technical director of KS-V Peptide, was invited to share a report of "Chemical Synthesis of Histon Related Peptides and Proteins with Post-translational Modifications" at the symposium. Dr. Guo introduced the professional R&D team and products such as ubiquitin and modified histone of KS-V Peptide at the end of his report as well. After the report, many teachers and students from Harvard University, Wuhan University, BSC and other universities or research institutes came to our company's booth for technical communication and business consultation. In order to enliven the atmosphere and let the participants communicate in a relaxed and pleasant mood during the coffee break time, KS-V Peptide specially prepared the lottery for the participants. KS-V Peptide will continue to strengthen the cooperation between the academic and business communities, and make a contribute to the prosperity and development of pharmaceutical industry.
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  • Congratulations to Pro. Lu Chao’s team for their article published on Nature
    Congratulations to Pro. Lu Chao’s team for their article published on Nature Sep 05, 2019
    Recently, Lu Chao’s team have published their paper on Nature entitled "The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape". Enzymes that catalyse CpG methylation in DNA, including the DNA methyltransferases 1 (DNMT1), 3A (DNMT3A) and 3B (DNMT3B), are indispensable for mammalian tissue development and homeostasis. They are also implicated in human developmental disorders and cancers, supporting the critical role of DNA methylation in the specification and maintenance of cell fate. Previous studies have suggested that post-translational modifications of histones are involved in specifying patterns of DNA methyltransferase localization and DNA methylation at promoters and actively transcribed gene bodies. However, the mechanisms that control the establishment and maintenance of intergenic DNA methylation remain poorly understood. Tatton–Brown–Rahman syndrome (TBRS) is a childhood overgrowth disorder that is defined by germline mutations in DNMT3A. TBRS shares clinical features with Sotos syndrome (which is caused by haploinsufficiency of NSD1, a histone methyltransferase that catalyses the dimethylation of histone H3 at K36 (H3K36me2), which suggests that there is a mechanistic link between these two diseases. Here we report that NSD1-mediated H3K36me2 is required for the recruitment of DNMT3A and maintenance of DNA methylation at intergenic regions. Genome-wide analysis shows that the binding and activity of DNMT3A colocalize with H3K36me2 at non-coding regions of euchromatin. Genetic ablation of Nsd1 and its paralogue Nsd2 in mouse cells results in a redistribution of DNMT3A to H3K36me3-modified gene bodies and a reduction in the methylation of intergenic DNA. Blood samples from patients with Sotos syndrome and NSD1-mutant tumours also exhibit hypomethylation of intergenic DNA. The PWWP domain of DNMT3A shows dual recognition of H3K36me2 and H3K36me3 in vitro, with a higher binding affinity towards H3K36me2 that is abrogated by TBRS-derived missense mutations. Together, our study reveals a trans-chromatin regulatory pathway that connects aberrant intergenic CpG methylation to human neoplastic and developmental overgrowth. We are honored to provide the H3 post-translational modified histones for the research. We can also provide you with customized synthetic services for functional proteins and polypeptides,like H3,H3-K4me1,H2A-K119Ub,CENPA-S17ph. KS-V Peptide specializes in providing customized synthesis of difficult peptides , modification and optimization of pharmaceutical peptide and development of peptide technology for universities, research institutes and biopharmaceutical companies. Link for the article:https://doi.org/10.1038/s41586-019-1534-3
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  • KS-V Peptide won the second prize in the Final of Hefei District Competition of the 8th China Innovation and Entrepreneurship Competition
    KS-V Peptide won the second prize in the Final of Hefei District Competition of the 8th China Innovation and Entrepreneurship Competition Jul 31, 2019
    On July 30th, it successfully held the “Technology Bank Cup”of the 8th China Innovation and Entrepreneurship Competition of Hefei District in Hefei. All the companies selected for the final are outstanding. Most researchs of the enterprises’ core teams are highly educated talents,doctors of Science and Technology University of China, Harvard University's post-doctoral research talents, and the world's original technology,for instance. With the top peptide synthesis technology and broad market prospects, KS-V Peptide has won the second prize of Biomedicine Group. KS-V Peptide have a first-class scientific research and has rich experience in production, management, marketing team,we will create a new chapter of innovation and entrepreneurship in Hefei,namely to contribute  to create innovative cities with a mode of science and technology.
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