We can provide innovative drugs from gene to protein, from gene to structure, from structure to lead compound to new drug preclinical candidate drug and other services, and efficiently promote the discovery of innovative drug candidates.
● Construct design with all commercially available vectors
● Multiple tags, inserts, mutations, deletes, and multi-parallel construct design
● High capacity protein expression in E Coli, Insect cells, and mammalian cells
● Automatic protein purification by AKTA.
● Double stand DNA purification
● Post-treatment of protein for crystallization: Protein refolding, dephosphorylation, and deglycosylation
● 13C, 2H, and 15N Labeled proteins for NMR
● Membrane protein purification from over 70 GPCR stable cell lines, 50 human gene targets.
● Endotoxin-free protein purification (Final endotoxin as low as 0.1EU/mg)
● Off-the-Shelf protein production service
● Purity of >90% achieved ● SDS-PAGE
● Analytic UPLC ● LC-MS
● Peptide mapping and sequencing ● DLS, CD, and related biochemical assay
● Western Blotting with Anti-His, Anti-GST and Anti-bio, etc antibodies
We have several methods are used to determine the structure of a biomacromolecule, including Nuclear Magnetic Resonance (NMR) spectroscopy and Cryogenic Electron Microscopy (cryo-EM).
We have the most complete and state-of-the-art platform and professional knowledge cluster.
After finished the study, we will provide you with the confidential structural determination report:
–A report of the process of the different phase