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PDC drugs, peptide drug conjugate complex (Peptide Drug Conjugate), is to couple targeted peptides and drug molecules to enhance the targeting of drugs, concentrate the drugs on the target tissues and reduce their relative concentration in other tissues.Improve effectiveness and reduce adverse reactions.


The main research directions of PDC drugs are anti-tumor drugs and tumor vascular expression specific markers.Polypeptide carrier targeted drugs is known as one of the new generation of targeted specific anti-tumor drugs.Compared with ADC drugs, PDC drugs have the following advantages: they have lower molecular weight (generally less than 3kD), higher drug loading, lower immunogenicity, and lower production costs.


Drug molecules in PDC drugs are divided into chemical drugs and non-chemical drugs.Tumor targeting peptide-conjugated drugs generally use cytotoxic drugs, such as paclitaxel, camptothecin, doxorubicin, and chlorambucil.The cytotoxic loads of non-chemical drugs are often TNF, interfering small RNA (siRNA) and antisense oligonucleotides (AONs).

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