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(1) Custom peptide library based on known structure


Based on the structure of known compounds, a series of polypeptides are constructed and designed including but not limited to the following methods, and screened for the functions and indications of the target compound, in order to obtain new molecules or new structures with target drug effects.


N-terminal, C-terminal, side chain modification: acylation, esterification, PEGylation, beta-amino acid substitution, D amino acid substitution, main chain amino methylation, disulfide bond substitution, conformation locking (helix, beta-sheet) , Mirrored peptides, cyclic peptides (end-to-end cyclization, side chain cyclization), special molecular markers, hydroxyl acid substitution.


(2) Phage display peptide library


Artificially synthesize genes encoding random polypeptide segments, then clone these genes into phage vectors, and display the polypeptides one by one on the surface of the phage through phage epitope display technology to construct a polypeptide library. When screening, based on the specific interaction between a specific receptor target and certain peptides in the peptide library, the peptides that bind to the specific target are screened from the library.


(3) One-bead One-compound chemical combination peptide library


Combinatorial library is a peptide library in which tens of thousands of peptides are synthesized by random synthesis of peptides on the resin. For example, a 5-peptide library would have 55 pentapeptides, and a 9-peptide library would have 99 nonapeptides. Then, during screening, based on the specific interaction between the specific receptor target and certain peptides in the peptide library, the peptides that bind to the specific target are screened out.


(4) DNA-encoded chemical combination peptide library


Polypeptides are randomly synthesized on the carrier resin and also contain a peptide library composed of thousands of polypeptides and DNA synthesized by DNA. Each amino acid will be synthesized corresponding to several nucleotides to encode the information of the polypeptide. When screening, the receptor target needs to be connected to a fluorescent molecule. If a peptide binds to the receptor, the corresponding resin will have fluorescence. Then use these fluorescent resins as templates for PCR amplification, and then sequence to obtain peptide information.

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Please send us your inquiry(including peptide sequences,purity,quantity,modifications notes, etc.)by message. We will contact  you as soon as possible, usually in 24h in working days. Please send the email to: sales@difficultpeptide.com for bulk order of peptides. Thank you!
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