Calcicludine (Calcicludine, L-type Ca2+ channel blocker)
Any aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Shipped at room temperature. The product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Storage of solutions
Up to two weeks at 4°C or three months at -20°C.
WQPPWYCKEPVRIGSCKKQFSSFYFKWTAKKCLPFLFSGCGGNANRFQTIGECRKKCLGK (Disulfide bonds between Cys7-Cys57, Cys16-Cys40 and Cys32-Cys53)
Calcicludine (CAC) is a 60-amino acid polypeptide from the venom of Dendroaspis angusticeps. Calcicludine, a venom peptide of the Kunitz-type protease inhibitor family, is a potent blocker of high-threshold Ca2+ channels with a high affinity for L-type channels in cerebellar granule neurons.