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CAT | H1300 |
Product Name | Histone H2A |
Purity | ≥95% by HPLC analysis |
Appearance | White powder |
Usage | Research use only |
Storage | Shipping at room temperature. Upon delivery aliquot. Stored at -20°C or -80°C. Avoid freeze/thaw cycle. |
Sequence | SGRGKQGGKA RAKAKTRSSR AGLQFPVGRV HRLLRKGNYA ERVGAGAPVY LAAVLEYLTA EILELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLGKV TIAQGGVLPN IQAVLLPKKT ESHHKAKGK |
Histone H2A is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. H2A is important for packaging DNA into chromatin and has been found to regulate gene expression.
Histone ubiquitination, one of the histone post-transcriptional modifications, has been discovered for more than three decades. As histones are the most abundant ubiquitinated proteins, their ubiquitination plays a critical role in many processes in the nucleus, involving transcription, maintenance of chromatin structure, and DNA repair.
Monoubiquitination of H2A and H2B have been clearly implicated in transcriptional regulation. H2Aub occupation is more frequently correlated with gene silencing. In addition to polyubiquitination, monoubiquitination of histones H2A, H2B, and H2AX also occurs at the sites of DNA damage. The common ubiquitination of H2A is H2A.Z K121Ub, H2AK13Ub, H2AK15Ub, H2AK119Ub.
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