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Hefei KS-V Peptide Biological Technology Co., Ltd. Hefei KS-V Peptide Biological Technology Co., Ltd.
Hefei KS-V Peptide Biological Technology Co., Ltd.
H2AK15Ub
Products

SPECIFICATION OF H2AK15Ub


CAT

H1402

Product Name

Histone H2A-K15Ub

Purity

≥95% by HPLC analysis

Appearance

White powder

Usage

Research use only

Storage

Shipping at room temperature.

Upon delivery aliquot.

Stored at -20°C or -80°C.

Avoid freeze/thaw cycle.

Sequence

SGRGKQGGKA RAKAK(Ub)TRSSR AGLQFPVGRV HRLLRKGNYA ERVGAGAPVY LAAVLEYLTA EILELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLGKV TIAQGGVLPN IQAVLLPKKT ESHHKAKGK


APPLICATION OF H2AK15Ub

Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. RNF168-mediated ubiquitination of histone H2A Lys13,15 (H2AK13,15ub) at DNA double-strand breaks (DSBs) is crucial for preventing aberrant DNA repair and maintaining genome stability. USP51 is the DUB for H2AK13,15ub and regulates DNA damage response. 53BP1 recruitment to DSBs is triggered by RNF168-mediated ubiquitylation of histone H2A lysine 15 in the nucleosome core particle (NCP) constitutively dimethylated at histone H4 lysine 20 (NCPH2AK15ubH4K20me2), modifications recognized by 53BP1.


  • APPLICATION OF H2AK15Ub
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