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CAT | H1402 |
Product Name | Histone H2A-K15Ub |
Purity | ≥95% by HPLC analysis |
Appearance | White powder |
Usage | Research use only |
Storage | Shipping at room temperature. Upon delivery aliquot. Stored at -20°C or -80°C. Avoid freeze/thaw cycle. |
Sequence | SGRGKQGGKA RAKAK(Ub)TRSSR AGLQFPVGRV HRLLRKGNYA ERVGAGAPVY LAAVLEYLTA EILELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLGKV TIAQGGVLPN IQAVLLPKKT ESHHKAKGK |
Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. RNF168-mediated ubiquitination of histone H2A Lys13,15 (H2AK13,15ub) at DNA double-strand breaks (DSBs) is crucial for preventing aberrant DNA repair and maintaining genome stability. USP51 is the DUB for H2AK13,15ub and regulates DNA damage response. 53BP1 recruitment to DSBs is triggered by RNF168-mediated ubiquitylation of histone H2A lysine 15 in the nucleosome core particle (NCP) constitutively dimethylated at histone H4 lysine 20 (NCPH2AK15ubH4K20me2), modifications recognized by 53BP1.
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