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CAT | H1301 |
Product Name | Histone H2AY57ph |
Purity | ≥95% by HPLC analysis |
Appearance | White powder |
Usage | Research use only |
Storage | Shipping at room temperature. Upon delivery aliquot. Stored at -20°C or -80°C. Avoid freeze/thaw cycle. |
Sequence | SGRGKQGGKA RAKAKTRSSR AGLQFPVGRV HRLLRKGNYA ERVGAGAPVY LAAVLEY(ph)LTA EILELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLGKV TIAQGGVLPN IQAVLLPKKT ESHHKAKGK |
Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function.H2A-Y57ph inhibits deubiquitination of H2B by the SAGA complex as well as restricting demethylation of H3 and increasing its acetylation. Based on CK2 dependent tyrosine57 phosphorylation of H2A, a new transcriptional elongation regulator can be identified.
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