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CAT | H2300 |
Product Name | Histone H2B |
Purity | ≥95% by HPLC analysis |
Appearance | White powder |
Usage | Research use only |
Storage | Shipping at room temperature. Upon delivery aliquot. Stored at -20°C or -80°C. Avoid freeze/thaw cycle. |
Sequence | PEPAKSAPAP KKGSKKAVTK AQKKDGKKRK RSRKESYSVY VYKVLKQVHP DTGISSKAMG IMNSFVNDIF ERIAGEASRL AHYNKRSTIT SREIQTAVRL LLPGELAKHA VSEGTKAVTK YTSSK |
Histone H2B is one of the four main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and long N-terminal and C-terminal tails, H2B is involved with the structure of the nucleosomes and helps organize eukaryotic DNA. It plays an important role in the biology of the nucleus where it is involved in the packaging and maintaining of chromosomes, regulation of transcription, and replication and repair of DNA.
H2BUb is mostly associated with transcription activation. In addition to transcription regulation, monoubiquitinated H2B is also required for chromatin function in other ways. H2Bub has the role of chromatin boundary integrity, and loss of H2Bub leads to the spreading of different types of histone modifications. H2Bub is also shown to play an important role in homologous recombination through chromatin remodeling by recruiting chromatin remodeling factors. The common ubiquitination of H2B is H2BK34Ub, H2BK120Ub.
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