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CAT | H2401 |
Product Name | Histone H2B-K34Ub |
Purity | ≥95% by HPLC analysis |
Appearance | White powder |
Usage | Research use only |
Storage | Shipping at room temperature. Upon delivery aliquot. Stored at -20°C or -80°C. Avoid freeze/thaw cycle. |
Sequence | PEPAKSAPAP KKGSKKAVTK AQKKDGKKRK RSRK(Ub)ESYSVY VYKVLKQVHP DTGISSKAMG IMNSFVNDIF ERIAGEASRL AHYNKRSTIT SREIQTAVRL LLPGELAKHA VSEGTKAVTK YTSSK |
Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H2B-K34ub modification is sufficient to promote selective eviction of only one H2A/H2B dimer independently of histone-binding agents. H2B K34 ubiquitylation significantly enhances nucleosome dynamics and promotes the generation of hexasomes both with symmetrically or asymmetrically modified nucleosomes.
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