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CAT | H2301 |
Product Name | Histone H2B-S14ph |
Purity | ≥95% by HPLC analysis |
Appearance | White powder |
Usage | Research use only |
Storage | Shipping at room temperature. Upon delivery aliquot. Stored at -20°C or -80°C. Avoid freeze/thaw cycle. |
Sequence | PEPAKSAPAP KKGS(ph)KKAVTK AQKKDGKKRK RSRKESYSVY VYKVLKQVHP DTGISSKAMG IMNSFVNDIF ERIAGEASRL AHYNKRSTIT SREIQTAVRL LLPGELAKHA VSEGTKAVTK YTSSK |
Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. Phosphorylation of histone H2B at serine 14 (H2B-S14Ph) is associated with DNA damage and induces apoptotic chromatin condensation. H2B-S14Ph also correlates with class switch recombination and somatic hypermutation in germinal center B cells.
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