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Hefei KS-V Peptide Biological Technology Co., Ltd. Hefei KS-V Peptide Biological Technology Co., Ltd.
Hefei KS-V Peptide Biological Technology Co., Ltd.
H3K27me2
Products

SPECIFICATION OF H3K27me2


CAT

H3108

Product Name

Histone H3-K27me2

Purity

≥95% by HPLC analysis

Appearance

White powder

Usage

Research use only

Storage

Shipping at room temperature.

Upon delivery aliquot.

Stored at -20°C or -80°C.

Avoid freeze/thaw cycle.

Sequence

ARTKQTARKS TGGKAPRKQL ATKAARK(me2)SAP ATGGVKKPHR YRPGTVALRE IRRYQKSTEL LIRKLPFQRL VREIAQDFKT DLRFQSSAVM ALQEACEAYL VGLFEDTNLC AIHAKRVTIM PKDIQLARRI RGERA



APPLICATION OF H3K27me2

H3K27me2 is broadly distributed within the core histone H3 and is believed to play a protective role by inhibiting non-cell-type specific enhancers. Ultimately, this leads to the inactivation of transcription. In mouse embryonic stem cells, H3K27me2 is the dominant modification form, reaching 70%, while H3K27me1 and H3K27me3 only occupy 7 and 4% of the total H3, respectively. H3K27me3 is mainly enriched within the promoters of silenced genes; conversely, H3K27me1 and H3K27ac accumulate on transcriptionally active genes. PHF20L1 is a histone methylation reader protein, which recognizes H3K27me2 and collaborates with PRC2 and the NuRD complex in regulating H3K27 modifications to suppress a series of tumor suppressors, ultimately promoting the Warburg effect and breast tumorigenesis.


  • APPLICATION OF H3K27me2
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