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CAT | H32401 |
Product Name | Histone H3-K56ac-K122Ub |
Purity | ≥95% by HPLC analysis |
Appearance | White powder |
Usage | Research use only |
Storage | Shipping at room temperature. Upon delivery aliquot. Stored at -20°C or -80°C. Avoid freeze/thaw cycle. |
Sequence | ARTKQTARKS TGGKAPRKQL ATKAARKSAP ATGGVKKPHR YRPGTVALRE IRRYQK(ac)STEL LIRKLPFQRL VREIAQDFKT DLRFQSSAVM ALQEACEAYL VGLFEDTNLC AIHAKRVTIM PK(Ub)DIQLARRI RGERA |
H3 Lys56 acetylation increases the binding affinity of H3 toward two other chaperones CAF-1 and Rtt106. Meanwhile, H3 Lys56 acetylation promotes H3 Lys122 ubiquitination, which weakens the interaction between H3 and Asf1. Subsequently, Lys56 acetylation and Lys122 ubiquitination synergistically facilitate the transfer of the H3–H4 dimer from the H3–H4–Asf1 complex to other chaperones for (H3–H4)2 tetramer formation and deposition.
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