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CAT | H3114 |
Product Name | Histone H3-K79me2 |
Purity | ≥95% by HPLC analysis |
Appearance | White powder |
Usage | Research use only |
Storage | Shipping at room temperature. Upon delivery aliquot. Stored at -20°C or -80°C. Avoid freeze/thaw cycle. |
Sequence | ARTKQTARKS TGGKAPRKQL ATKAARKSAP ATGGVKKPHR YRPGTVALRE IRRYQKSTEL LIRKLPFQRL VREIAQDFK(me2)T DLRFQSSAVM ALQEACEAYL VGLFEDTNLC AIHAKRVTIM PKDIQLARRI RGERA |
Lysine 79 of histone H3 can be mono-, di- or trimethylated by Dot1 methylase; methylation at this residue acts as a marker of inactive chromatin regions that are critical for transcriptional silencing, and it is thought that silencing proteins such as Sir3 function by blocking Dot1 methylation. DOT1L-mediated H3K79me2 modification drives cardiomyogenesis through the definition of a specific transcriptional landscape.
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