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CAT | H3115 |
Product Name | Histone H3-K9me3-K18Ub |
Purity | ≥95% by HPLC analysis |
Appearance | White powder |
Usage | Research use only |
Storage | Shipping at room temperature. Upon delivery aliquot. Stored at -20°C or -80°C. Avoid freeze/thaw cycle. |
DNA methylation and histone modifications are two key epigenetic mechanisms in regulating gene expression, heterochromatin assembly, and genome stability. In mammals, maintenance of DNA methylation is mainly mediated by DNA methyltransferase 1 (DNMT1) in a replication-dependent manner. The spatiotemporal regulation of DNMT1 is essential for faithful propagation of DNA methylation patterns between cell generations. H3K9me3 by the RFTS domain of DNMT1 serves to enhance the enzymatic stimulation of DNMT1 by previously characterized H3 ubiquitylation and mediates the cellular colocalization of DNMT1 and H3K9me3.
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