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CAT | H3302 |
Product Name | Histone H3-T118ph |
Purity | ≥95% by HPLC analysis |
Appearance | White powder |
Usage | Research use only |
Storage | Shipping at room temperature. Upon delivery aliquot. Stored at -20°C or -80°C. Avoid freeze/thaw cycle. |
Sequence | ARTKQTARKS TGGKAPRKQL ATKAARKSAP ATGGVKKPHR YRPGTVALRE IRRYQKSTEL LIRKLPFQRL VREIAQDFKT DLRFQSSAVM ALQEACEAYL VGLFEDTNLC AIHAKRVT(ph)IM PKDIQLARRI RGERA |
Histone modifications are associated with distinct transcription states and serve as heritable epigenetic markers for chromatin structure and function. H3T118ph alters nucleosome dynamics and remodeling. H3T118ph dramatically decreases DNA–octamer binding increases nucleosome sliding and increases DNA accessibility near the nucleosome dyad. H3T118ph may function to destabilize nucleosomes in vivo by regulating their mobility, disassembly, and remodeling.
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