SEARCH
ENGLISH
CAT | U1040 |
Product Name | Ub-Prg |
Purity | ≥95% by HPLC analysis |
Appearance | Lyophilized powder |
Usage | Research use only |
Storage | Shipping at room temperature. Upon delivery aliquot. Stored at -20°C or -80°C. Avoid freeze/thaw cycle. |
Ub-Prg (also called Ub-PA) can react with the active Cys of DUBs through 1,2-addition to produce a stable vinyl thioether product. To explain regulatory mechanisms, Ub-Prg was used to capture the catalytic conformation by which RPN13DEUBAD activates UCH-L5; and the catalytic conformation that truncated INO80DEUBAD lacks to inhibit UCH-L5.
English 