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Hefei KS-V Peptide Biological Technology Co., Ltd.
Ubiquitins and Ubiquitin Probes

Ubiquitins and Ubiquitin Probes

Ubiquitin, ubiquitin chains, and their derivatives are indispensable molecular tools for studying the structure and function of proteins ubiquitylation. In order to overcome the barriers that such molecules are difficult to synthesize, our company has developed a series of Ubiquitin-related products with high purity, homogeneity, and definite structure on the basis of proteins chemical synthesis technology, ranging from μg to g grade with 70% to 99% purity. They can be used in basic research and drug discovery, which help you with drugs screening and related scientific research experiments.

What is the Purpose of Ubiquitination?

What is the Purpose of Ubiquitination?

Ubiquitins can be used in basic research and drug discovery, which help you to drugs screening and related scientific research experiments.

What is the Function of Ubiquitination?

What is the Function of Ubiquitination?

Ubiquitin, ubiquitin chains and their derivatives are indispensable molecular tools for studying the structure and function of proteins Ubiquitylation. In order to overcome the barriers that such molecules are difficult to synthesize, our company has developed a series of Ubiquitin-related products with high purity, homogeneity and definite structure on the basis of proteins chemical synthesis technology, ranging from μg to g grade with 70% to 99% purity. 

OTHER SYNTHETIC SERVICES ABOUT Ubiquitins and Ubiquitin

Ubiquitin chains of different lengths and types can be applied to biochemical functions such as interaction and enzyme activity as well as structural biology study of crystals, electron microscopes, and Nuclear Magnetic Resonance.

Ubiquitin-derived cross-linking probes can be used to detect unknown interacting proteins from normal or diseased cells and new targets for disease treatment.

Ubiquitin-derived fluorescent probes can be used to analyze the activity and specificity of deubiquitinase and high throughput screening of deubiquitinase inhibitors.


Types of Ubiquitination

Cellular Signaling

momo

DNA repair, endocytosis, histone regulation, virus budding, proteasomal and lysosome degradation

K63

Cell signaling/kinase activation and cytokine signaling, DNA damage response, endocytosis

K48

Proteasome degradation

K33

Immune regulation

K29

Lysosomal degradation, Wnt signaling

K27

The physiological function is not yet clear

K11

Cell Cycle/Proteasomal degradation, ERAD, cell signaling such as TNF and Wnt signaling

K6

The physiological function is not yet clear; however, it has been suggested to inhibit proteasomal degradation and involvement in DNA damage repair

linear

Regulation of NF-κB signaling in inflammation, protein degradation

multi-momo

Endocytosis, proteasomal and lysosomal degradation

mixed chains

MHC endocytosis (K11/K63), kinase activation (K33/K29)

lysine-less

Proteasomal degradation


Ubiquitins and Ubiquitin


The advantages of pseudo-isopeptide bond products are as follows:

  • Low cost and high purity

  • Does not affect the recognition of substrate by ubiquitin recognition enzymes

  • Can be cleaved by the deubiquitinase


We offer the following products:

  • Multi-ubiquitin Chain Products Linked by Pseudoisopeptide Bonds

  • Ubiquitins Modified Histones Linked by Pseudoisopeptide Bonds


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