English 
Ubiquitin, ubiquitin chains, and their derivatives are indispensable molecular tools for studying the structure and function of proteins ubiquitylation. In order to overcome the barriers that such molecules are difficult to synthesize, our company has developed a series of Ubiquitin-related products with high purity, homogeneity, and definite structure on the basis of proteins chemical synthesis technology, ranging from μg to g grade with 70% to 99% purity. They can be used in basic research and peptide drug discovery, which help you with drugs screening and related scientific research experiments.
Ubiquitins can be used in basic research and drug discovery, which help you to drugs screening and related scientific research experiments.
Ubiquitin, ubiquitin chains and their derivatives are indispensable molecular tools for studying the structure and function of proteins Ubiquitylation. In order to overcome the barriers that such molecules are difficult to synthesize, our company has developed a series of Ubiquitin-related products with high purity, homogeneity and definite structure on the basis of proteins chemical synthesis technology, ranging from μg to g grade with 70% to 99% purity.
Ubiquitin chains of different lengths and types can be applied to biochemical functions such as interaction and enzyme activity as well as structural biology study of crystals, electron microscopes, and Nuclear Magnetic Resonance.
Ubiquitin-derived cross-linking probes can be used to detect unknown interacting proteins from normal or diseased cells and new targets for disease treatment.
Ubiquitin-derived fluorescent probes can be used to analyze the activity and specificity of deubiquitinase and high throughput screening of deubiquitinase inhibitors.
Types of Ubiquitination | Cellular Signaling |
momo | DNA repair, endocytosis, histone regulation, virus budding, proteasomal and lysosome degradation |
K63 | Cell signaling/kinase activation and cytokine signaling, DNA damage response, endocytosis |
K48 | Proteasome degradation |
K33 | Immune regulation |
K29 | Lysosomal degradation, Wnt signaling |
K27 | The physiological function is not yet clear |
K11 | Cell Cycle/Proteasomal degradation, ERAD, cell signaling such as TNF and Wnt signaling |
K6 | The physiological function is not yet clear; however, it has been suggested to inhibit proteasomal degradation and involvement in DNA damage repair |
linear | Regulation of NF-κB signaling in inflammation, protein degradation |
multi-momo | Endocytosis, proteasomal and lysosomal degradation |
mixed chains | MHC endocytosis (K11/K63), kinase activation (K33/K29) |
lysine-less | Proteasomal degradation |
The advantages of pseudo-isopeptide bond products are as follows:
Low cost and high purity
Does not affect the recognition of substrate by ubiquitin recognition enzymes
Can be cleaved by the deubiquitinase
We offer the following products:
Multi-ubiquitin Chain Products Linked by Pseudoisopeptide Bonds
Ubiquitins Modified Histones Linked by Pseudoisopeptide Bonds
