Structure confirmation

The FDA's latest guidelines on peptide drugs propose that the secondary structure needs to be characterized on the basis of the primary sequence, including characterization data such as the amino acid sequence of the impurities and the secondary structure.At present, common methods for identifying the structure of polypeptides include crystal structure analysis and nuclear magnetic resonance analysis, among which nuclear magnetic resonance is the most direct and effective technical method for identifying the structure of the original drug solution.

(1) Service items:

  • Structural Identification of Active Ingredients in Polypeptide Medicine
  • Structure analysis of trace impurities

(2) Technology development:

  • Nuclear magnetic analysis method of peptide structure in original drug solution
  • Development of N15, C13, F19 isotopic labeling methods to resolve complex structures

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