Ubiquitin, ubiquitin chains and their derivatives are indispensable molecular tools for studying the structure and function of proteins Ubiquitylation. In order to overcome the barriers that such molecules are difficult to synthesize, our company has developed a series of Ubiquitin-related products with high purity, homogeneity and definite structure on the basis of proteins chemical synthesis technology, ranging from μg to g grade with 70% to 99% purity. They can be used in basic research and drug discovery, which help you to drugs screening and related scientific research experiments.


  • Ubiquitin chains of different lengths and types can be applied to biochemical functions such as interaction and enzyme activity  as well as structural biology study of crystals, electron microscopes and Nuclear Magnetic Resonance.


  • Ubiquitin-derived cross-linking probes can be used to detect unknown interacting proteins from normal or diseased cells and new targets for disease treatment.


  • Ubiquitin-derived fluorescent probes can be used to analyze the activity and specificity of deubiquitinase and high throughput screening of deubiquitinase inhibitors.


Ubiquitination Type Cellular Signaling
momo DNA repair, endocytosis, histone regulation, virus budding, proteasomal and lysosome degradation
K63 Cell signaling/kinase activation and cytokine signaling, DNA damage response, endocytosis
K48 Proteasome degradation
K33 Immune regulation
K29 Lysosomal degradation, Wnt signaling
K27 The physiological function is not yet clear
K11 Cell Cycle/Proteasomal degradation, ERAD, cell signaling such as TNF and Wnt signaling
K6

The physiological function is not yet clear; however, it has beensuggested to inhibit proteasomal degradation and involvement in DNA damage repair

linear Regulation of NF-κB signaling in inflammation, protein degradation
multi-momo Endocytosis, proteasomal and lysosomal degradation
mixedchains MHC endocytosis (K11/K63), kinase activation (K33/K29)
lysine-less Proteasomal degradation

Ubiquitins and Ubiquitin Probes

Product Catalogue
Ubiquitins and Ubiquitin Probes
CAT.#PRODUCTSEQUENCES
U1000 Ubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
U2101 Met1 Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
U2201 K6 Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
U2301 K11Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
U2401 K27Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
U2501 K29Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
U2601 K33 Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
U2701 K48 Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
U2801 K63 Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
U1010 UbAMC MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
U1020 Ub ACC MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
U1030 Ub Rho110 MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
U1040 Ub Prg MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
U1050 Ub Br2 MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
UD2201 DhaK6Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
UD2301 DhaK11Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
UD2401 Dha K27 Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
UD2501 Dha K29 Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
UD2601 Dha K33 Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
UD2701 Dha K48 Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
UD2801 Dha K63 Diubiquitin MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN IQKESTLHLV LRLRGG
  • Total and Semi-synthetic Ubiquitin Products of High Quality
  • Full set of Diubiquitin kit, including all types of diubiquitin products
  • If you need polyubiquitin chain synthesis services, please contact us.


Ubiquitin Products with Pseudoisopeptide Bond


Because of the high cost of isopeptide bond synthesis, we have developed a synthetic method of pseudoisopeptide bond with only one replacement of carbon atom by sulfur atom of the Lys side chain.


Ubiquitins and Ubiquitin Probes


The advantages of pseudo-isopeptide bond products are as follows:


  • Low cost and high purity
  • Does not affect the recognition of substrate by ubiquitin recognition enzymes
  • Can be cleaved by deubiquitinase


We offer the following products:


  • Multi-ubiquitin Chain Products Linked by Pseudoisopeptide Bonds
  • Ubiquitous Modified Histones Linked by Pseudoisopeptide Bonds



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Please send us your inquiry(including peptide sequences,purity,quantity,modifications notes, etc.)by message. We will contact  you as soon as possible, usually in 24h in working days. Please send the email to: sales@difficultpeptide.com for bulk order of peptides. Thank you!
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